Overview

Recently, it has been found that particular G-rich DNA (and RNA) sequences are capable of forming stable four-stranded structures known as G-quadruplexes. Introductory material on G-quadruplexes can be found on Wikipedia and Quadruplex.org (Links).

Here, we present a computational prediction method for the stability of G-quadruplexes using Gaussian processes. The method uses training-sequences from measured quadruplexes (data download) to predict the stability of unseen quadruplex sequences.

Online predictions

A BETA version of an online-predictor for quadruplex stability is available here.

Download

• Data table with training Quadruplexes (280):
  [xls] [csv]

Relevant Publications

• Oliver Stegle, Linda Payet, Jean-Louis Mergney, David J.C. MacKay, Julian L. Huppert
  Predicting and understanding the stability of G-quadruplexes .
  Bioinformatics (ISMB) 2009 to appear.
  [pdf]